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21 February 2025: PIB Summary For UPSC

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1. Common biomarker for range of Cancers offers potential non-invasive method for early cancer diagnosis

(Source – https://pib.gov.in/PressReleasePage.aspx?PRID=2104995 )

Topic: GS3 – Science and Technology
Context
  • Researchers have identified common metabolites in exosomes across different cancer types.
  • This discovery enables non-invasive early detection and targeted therapeutic strategies for improved cancer treatment.

Research on Universal Cancer Biomarkers:

  • Some cancers, like pancreatic and glioma, are diagnosed late, making treatment difficult.
  • Scientists found common substances (metabolites) in tiny messengers called exosomes, which cancer cells release.
  • These metabolites may act as universal markers to detect cancer early and develop better treatments.
  • Researchers studied exosomes from pancreatic, lung, and glioma cancer cells.
  • They used advanced techniques like imaging, mass spectrometry, and molecular analysis for accurate results.
  • The study helps understand how cancer spreads and interacts within the body.
  • These biomarkers can lead to precise, non-invasive cancer detection methods.
  • Targeted therapies could block harmful metabolic pathways, making treatments more effective with fewer side effects.
  • The findings support personalized medicine and better patient outcomes.
 What are biomarkers?
  • Biomarkers are measurable indicators of biological processes, diseases, or responses to treatment.
  • They can be molecules like proteins, genes, or metabolites found in blood, tissues, or body fluids.
  • Biomarkers help in early disease detection, diagnosis, and monitoring treatment effectiveness.
  • They are widely used in cancer research, cardiovascular diseases, and neurological disorders.
  • Some biomarkers indicate disease risk, while others track disease progression.
  • Non-invasive biomarkers, like those in blood or urine, are preferred for easy detection.
  • Biomarkers aid in developing personalized medicine and targeted therapies.
  • Examples include glucose for diabetes, PSA for prostate cancer, and troponin for heart attacks.
Practice Question:  What are biomarkers, and how do they contribute to early disease detection and personalized medicine? Discuss their significance in modern healthcare. (150 Words /10 marks)

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